For efficiency, speed, and cost, many sows involve "REPURPOSING FDA APPROVED TREATMENTS"

 Over the past few years, a number of products that signal a new era of medical research and development have entered the markets and are on the horizon. 

 Germline mutations of the LKB1 tumor suppressor gene result in Peutz–Jeghers Syndrome (PJS) characterized by intestinal hamartomas and increased incidence of epithelial cancers. 

 Germline mutations of the LKB1 tumor suppressor gene lead to Peutz-Jeghers Syndrome (PJS) with a predisposition to cancer.  

 LKB1 is commonly thought of as a tumor suppressor gene because its hereditary mutation is responsible for cancer syndrome, and somatic inactivation of LKB1 is found in non-small cell lung cancer, melanoma, and cervical cancers. 

 Increasing evidence has highlighted that deficiency of LKB1 in cancer cells induces extensive metabolic alterations that promote tumorigenesis and development. 

 Physiologically, LKB1 possesses multiple cellular functions in the regulation of cell bioenergetics metabolism, cell cycle arrest, embryo development, cell polarity, and apoptosis. 

The molecular identification of human cancer antigens has allowed the development of antigen-specific immunotherapy. 

We demonstrate CRISPR-Cas9-mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia.

 The PAR clan of polarity regulating genes was initially discovered in a genetic screen searching for genes involved in asymmetric cell divisions in the Caenorhabditis elegans embryo.  

The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases.

Does  autophagy take a front seat in lifespan extension? 

 Somatic mutations or deregulated expression of chromatin modifying enzymes are being identified at high frequency. 

 Human embryonic stem cells maintained on human amniotic epithelial cells (hESCshAEC) are better preserved in an undifferentiated state and... 

 Epigenetic therapies may play a prominent role in the future management of solid tumors. 

To stop lung cancer from spreading, researchers target a specific gene. 

By Adam Marcus, PhD

Gene discovery may stop the spread of lung cancer.

By Reuben Shaw, PhD